李亚东等发现下丘脑促进海马骨骼肌发生可调控学习记忆和焦虑

，不够佳认知灵活性的新策略。通过珍贵环境、革新运动等提很低呼唤的新方法仅或许达到提很低认知的旨在。不够为不可忽视的是，该策略可以运用于干预乌拉兹海默病中期由突触丢失引致的的认知障碍。

李德里和罗艳佳耶鲁大学为论文共同完成第一作者，宋娟为唯一无线电作者。该科学研究受益复旦大学黄志力课题组在形体Spike详细描述技术支持。

李德里耶鲁大学关注呼唤必要以及呼唤仰赖性研读知觉和心灵的脑交叉点科学研究，常用在形体电生理详细描述、很低分辨率单/双暗子成像、在形体多通道钠信号详细描述、生物科学和暗/化学性状学借助新方法等技术，揭示了腹侧二阶脑节交叉点仰赖性事实涉及呼唤的不可忽视主导作用(5, 6)（Molecular Psychiatry，2021；Nature Communications，2018）；辨认出血清素呼唤交叉点加强海燕脑愈演愈烈、不够佳知觉萃取灵活性的主导作用和独特必要，提议了通过提很低呼唤素质，加强海燕脑愈演愈烈不够佳研读知觉的新思路（eLife，2020；Nature Neuroscience，2022）。

当年期另据：Mol Psychiatry：复旦黄志力组辨认出腹侧苍白球仰赖性事实使用暴力和呼唤

澳大利亚新罕布夏大学教堂山所学校宋娟课题组诚聘访问学者，详细信息请参见：

宋娟课题组近几年的杰作：

1. Asrican B#, Wooten J#, Li Y, Quintanilla L, Zhang F, Bao H, Yeh CY, Wander C, Luo YJ, Olsen RHJ, Lim SA, Jin P, Song J* (2020). Neuropeptides modulate local astrocytes to regulate hippocampal neural stem cells. Neuron 108(2):349-366.

2. Li Y, Bao H, Luo Y, Yoan C, Sullivan HA, Quintanilla L, Wickersham IR, Lazarus M, Shin YY, Song J* (2020). Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release. eLife doi: 10.7554/eLife.53129.

3. Yeh CY#, Asrican B#, Moss J, Quintanilla L, He T, Mao X, Cassé F, Gebara E, Bao H, Lu W, Toni N, Song J* (2018). Mossy cells control neural stem cell quiescence and maintenance through a dynamic balance between direct and indirect pathways. Neuron 99(3):493-510 (Featured article, issue highlights).

4. Bao H#, Asrican B#, Li W#, Gu B, Wen ZX, Lim ZA, Haniff I, Ramakrishnan C, Deisseroth K, Philpot B, Song J* (2017). Long-range GABAergic inputs regulate neurl stem cell quiescence and control hippocampal neurogenesis. Cell Stem Cell 21(5):604-617 (Cover article, featured article, issue highlights, recommended by F1000, selected as Best Articles in 2017 in Cell Stem Cell).

参见文献（上下滑动查看）：

1. J. S. Farrell, M. Lovett-Barron, P. M. Klein, F. T. Sparks, T. Gschwind, A. L. Ortiz, B. Ahanonu, S. Bradbury, S. Terada, M. Oijala, E. Hwaun, B. Dudok, G. Szabo, M. J. Schnitzer, K. Deisseroth, A. Losonczy, I. Soltesz, Supramammillary regulation of locomotion and hippocampal activity. Science 374, 1492-1496 (2021); published online EpubDec 17 (10.1126/science.abh4272).

2. S. Chen, L. He, A. J. Y. Huang, R. Boehringer, V. Robert, M. E. Wintzer, D. Polygalov, A. Z. Weitemier, Y. Tao, M. Gu, S. J. Middleton, K. Namiki, H. Hama, L. Therreau, V. Chevaleyre, H. Hioki, A. Miyawaki, R. A. Piskorowski, T. J. McHugh, A hypothalamic novelty signal modulates hippocampal memory. Nature 586, 270-274 (2020); published online EpubOct (10.1038/s41586-020-2771-1).

3. N. P. Pedersen, L. Ferrari, A. Venner, J. L. Wang, S. B. G. Abbott, N. Vujovic, E. Arrigoni, C. B. Saper, P. M. Fuller, Supramammillary glutamate neurons are a key node of the arousal system. Nature communications 8, 1405 (2017); published online EpubNov 10 (10.1038/s41467-017-01004-6).

4. Y. Li, H. Bao, Y. Luo, C. Yoan, H. A. Sullivan, L. Quintanilla, I. Wickersham, M. Lazarus, Y. I. Shin, J. Song, Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release. Elife 9, (2020); published online EpubFeb 26 (10.7554/eLife.53129).

5. Y. D. Li, Y. J. Luo, W. Xu, J. Ge, Y. Cherasse, Y. Q. Wang, M. Lazarus, W. M. Qu, Z. L. Huang, Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway. Molecular psychiatry, (2020); published online EpubOct 14 (10.1038/s41380-020-00906-0).

6. Y. J. Luo, Y. D. Li, L. Wang, S. R. Yang, X. S. Yuan, J. Wang, Y. Cherasse, M. Lazarus, J. F. Chen, W. M. Qu, Z. L. Huang, Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors. Nature communications 9, 1576 (2018); published online EpubApr 20 (10.1038/s41467-018-03889-3).

7. Y. D. Li, Y. J. Luo, Z.K. Chen, L. Quintanilla, Y. Cherasse , L. Zhang, MLazarus, Z.L. Huang, J. Song, Hypothalamic modulation of hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behior. Nature Neuroscience, (2022) ; published online Epub May 6, (10.1038/s41593-022-01065-x).

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